KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
POLE2
All Species:
37.27
Human Site:
Y254
Identified Species:
54.67
UniProt:
P56282
Number Species:
15
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P56282
NP_002683.2
527
59537
Y254
P
S
S
T
T
R
A
Y
Y
G
N
I
N
F
F
Chimpanzee
Pan troglodytes
XP_509931
527
59578
Y254
P
S
S
T
T
R
A
Y
Y
G
N
I
N
F
F
Rhesus Macaque
Macaca mulatta
XP_001095940
525
59213
Y257
P
S
S
T
T
R
A
Y
Y
G
N
I
N
F
F
Dog
Lupus familis
XP_851216
527
59504
Y254
P
S
S
T
T
R
A
Y
Y
G
N
V
N
F
F
Cat
Felis silvestris
Mouse
Mus musculus
O54956
527
59368
Y254
P
S
S
T
T
R
A
Y
Y
G
N
I
N
F
F
Rat
Rattus norvegicus
XP_216727
527
59187
Y254
P
S
S
T
T
R
A
Y
Y
G
N
I
N
F
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515002
535
60459
Y262
P
S
S
T
T
R
A
Y
Y
G
N
T
N
F
F
Chicken
Gallus gallus
Q5ZKQ6
527
59609
F254
P
S
A
T
T
R
A
F
Y
G
N
I
N
F
F
Frog
Xenopus laevis
NP_001083783
527
59670
Y254
P
S
S
T
T
R
A
Y
Y
G
N
M
N
F
F
Zebra Danio
Brachydanio rerio
NP_775353
527
59243
Y254
P
S
S
F
T
R
A
Y
F
G
N
V
N
F
F
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_647995
525
58740
F253
P
A
N
S
S
R
A
F
F
G
T
A
N
T
W
Honey Bee
Apis mellifera
XP_001120791
454
52119
E195
I
V
N
G
N
F
Q
E
G
V
L
H
V
E
N
Nematode Worm
Caenorhab. elegans
Q19196
534
60979
W249
E
L
S
S
N
E
N
W
F
G
G
D
D
K
I
Sea Urchin
Strong. purpuratus
XP_796825
501
56117
G234
F
G
N
L
N
F
F
G
G
P
S
A
T
C
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
NP_001147081
533
59891
L257
D
R
E
A
S
V
S
L
L
M
G
F
D
F
F
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P24482
689
78322
T358
R
R
E
I
T
L
E
T
I
G
N
L
D
L
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99
92.4
93.5
N.A.
90.1
90.8
N.A.
86.1
82.1
81
73.2
N.A.
42.1
39.2
30.8
57.6
Protein Similarity:
100
99.2
94.3
97.1
N.A.
94.8
95.2
N.A.
90.8
91.4
91
88
N.A.
59.7
58
51.1
75.7
P-Site Identity:
100
100
100
93.3
N.A.
100
100
N.A.
93.3
86.6
93.3
80
N.A.
33.3
0
13.3
0
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
93.3
100
100
93.3
N.A.
80
6.6
40
13.3
Percent
Protein Identity:
N.A.
36.2
N.A.
N.A.
24.3
N.A.
Protein Similarity:
N.A.
56.2
N.A.
N.A.
42.9
N.A.
P-Site Identity:
N.A.
13.3
N.A.
N.A.
20
N.A.
P-Site Similarity:
N.A.
33.3
N.A.
N.A.
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
7
7
0
0
69
0
0
0
0
13
0
0
7
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
7
0
% C
% Asp:
7
0
0
0
0
0
0
0
0
0
0
7
19
0
0
% D
% Glu:
7
0
13
0
0
7
7
7
0
0
0
0
0
7
0
% E
% Phe:
7
0
0
7
0
13
7
13
19
0
0
7
0
69
69
% F
% Gly:
0
7
0
7
0
0
0
7
13
82
13
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
7
0
0
0
% H
% Ile:
7
0
0
7
0
0
0
0
7
0
0
38
0
0
7
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
7
0
% K
% Leu:
0
7
0
7
0
7
0
7
7
0
7
7
0
7
7
% L
% Met:
0
0
0
0
0
0
0
0
0
7
0
7
0
0
0
% M
% Asn:
0
0
19
0
19
0
7
0
0
0
69
0
69
0
7
% N
% Pro:
69
0
0
0
0
0
0
0
0
7
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
7
0
0
0
0
0
0
0
0
% Q
% Arg:
7
13
0
0
0
69
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
63
63
13
13
0
7
0
0
0
7
0
0
0
0
% S
% Thr:
0
0
0
57
69
0
0
7
0
0
7
7
7
7
0
% T
% Val:
0
7
0
0
0
7
0
0
0
7
0
13
7
0
0
% V
% Trp:
0
0
0
0
0
0
0
7
0
0
0
0
0
0
7
% W
% Tyr:
0
0
0
0
0
0
0
57
57
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _